DNA Did you know that there was a high quality diffraction of B-DNA made a year before Rosalind Franklin and Raymond Gosling generated photo 51? Elwyn Beighton and William Astbury generated a nearly flawless diffraction of B-DNA in 1951, a full year ahead of Franklin and Gosling. They never shared or published it.
Proteomics The Proteome: It's a bit more complex than any of us would like Translating the Proteome: There’s more to making proteins than just transcribing DNA into mRNA.
Protein Sequencing Sequencing proteins with nanopores is hard. Engineered nanopores might make it a little easier. Nanopores, what can't they do? Well, they're not very good at sequencing proteins. Yet.
Paid-members only Start-Upomics Featured RavGen got Natera to cough up $57m. What's going on with non-invasive screening test IP?
DNA Florence Bell and William Astbury's x-ray diffraction work on a 'pile of pennies' The first crystal structure of DNA was published in 1938. It was generated by Florence Bell, a scientist you need to know.
Proteomics The Proteome: It's a bit more complex than any of us would like Proteoforms: This is where things start to get complicated.
Epigenomics The epigenome's role in aging gets some mechanistic answers Feeling old? It might be time to blame your epigenome.
Paid-members only Conferenceomics Featured A round-up of everything omics that happened at the JP Morgan Healthcare Conference
DNA The story of Phoebus Levene, one of the mostly invisible grandfathers of nucleic acids Watson and Crick were the first to describe the structure of the DNA double helix. Their major contribution to science was, at its core, a synthesis of all of the best data available at the time.
Proteomics The Proteome: what it is and why protein structure is so important The Proteome: we can’t live without it, but, what actually is it?
DNA Pfizer developed a technique for determining the primary structure of their mRNA vaccine including detecting base modifications, the 5'-cap, and the poly-A tail Pfizer developed a new method to determine the primary structure of RNA. 'So, they made a sequencer?' Kinda.
Paid-members only Start-Upomics Featured 23andMe has been in the news recently about a data breach, raising important questions about data security in the age of genomics
Paid-members only Proteomics Featured It was a bad week for plasma proteomics darlings Olink and SomaLogic
DNA The story of the polymerase chain reaction and how sometimes timing is everything The method below has been cited more than 600,000 times and is one of the most important developments in the history of science.
Transcriptomics Single-Cell and Spatial Transcriptomics and why they’ve gotten so much attention recently Everything you need to know about the status quo and new kid on the block.
Genomics Genomics is better with friends **cough** transcriptomics, proteomics, metabolomics, and epigenomics **cough** Spoiler Alert: The future of disease early detection isn't going to be genomics
Genomics The story of how Solexa and Illumina combined forces to revolutionize the field of genomics Illumina is considered by many to have single handedly transformed the field of genomics. They did it by building on the foundation Solexa established in 1997.
Genomics Why magnetic beads are the most important reagent in genomics Magnetic beads don't get much respect in the sequencing world, but they're hella useful. Here are some applications you should try!
Pangenomics The human pangenome is finally here and, in my opinion, it was the biggest story of the year It's here! It's really here! The first draft of the human pangenome reference was released this year!
