A trip down the Omic rabbit hole

What’s in an 'ome?' Basically everything.

A trip down the Omic rabbit hole
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Naming an 'ome' was very popular in the late 90's and early 2000's, probably because that's right around when we all caught the 'Genome' bug.

But the majority of these 'omes' are derivatives or sub-omes of the major ones.

Some of these may only still exist in the mind of their creator, and don't get mad at me if I missed your favorite one - there are a lot!

What follows is a long list of the ones I've heard of before:

Antibodyome - All the antibodies in an organism

Cellome - The totality of molecules and their interactions within a cell

Chemome - The totality of chemicals in cells or organisms

Cytome - All the cells of a particular organism together with their associated cellular processes

Degradome - All the compounds produced in the degradation of a material (especially of a protease)

Embryome - All the cell types which arise during embryogenesis and development

Exome - The complete exon content of an organism or individual; the subset of the genome that excludes introns

Exposome - All of the effects of life-long environmental exposures on health

Glycome - All the polysaccharides, glycosides and carbohydrate-related compounds in an organism

Immunome - All the genes and proteins associated with an immune system

Interactome - All the interactions between biological entities in a cell or organism

Kinome - All the kinases expressed in a cell or contained in a genome

Lipidome - All the lipids in a cell or organism

Ligandome - All the molecular ligands for proteins in a cell or organism

Methylome - All the nucleic acid methylation modifications in an organism's genome

Microbiome - The community of microbes in or on an organism

Neurome - The totality of the neurons in an organism

Nosolome - The totality of diseases and their association network.

ORFeome - The totality of open reading frames in a genome

Pangenome - The genome of all the strains of a particular species

Paranome - The complete set of paralogous genes in a genome

Pharmacogenome - All the genes that are affected by pharmaceutical drugs

Phenome - The whole set of phenotypic entities in an organism

Regulome - The whole set of regulation components in an organism, usually used in the context of signal transduction

Reactome - All the biochemical reactions that take place within an organism

Secretome - All of proteins secreted from a cell

Signalome - All the signalling pathways of an organism or cell

Supergenome - All the genes encoded on an organism's chromosomes together with those encoded on mobile genetic elements

Toponome - The spatial network code of proteins in cells and tissues

Toxicome - The totality of toxic chemicals in cells

Ubiquitome - All the ubiquitin polypeptides that play a part in modifying and degrading proteins

There's even an 'ome' for people who hate the propagation of superfluous omes…the Antiome.

You can count me as a member.

Sorry, Padme.

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