High-Throughput Sequencing

A collection of 23 posts

Genetics

De novo mutations are more common than we previously thought

There’s more to de novo mutations (DNMs) than just SNPs and indels.

Oncology

Will Ultima's ultra cheap bases be a major boon to MRD?

Ultima Genomics is put to the test in MRD

High-Throughput Sequencing

The 'plus and minus' method: Fred Sanger's first attempt at DNA sequencing

Frederick Sanger invented a famous DNA sequencing method. It's not the one pictured below (which he also invented).

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High-Throughput Sequencing

Turnabout is fair play as Illumina gets caught up in a trade war kerfuffle

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High-Throughput Sequencing

What was buzzing at AGBT? Spatial, $80 Genomes, and Roche SBX

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Nanopore Wars

Roche have a new DNA sequencer. Should anyone care?

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High-Throughput Sequencing

Roche finally has something to say about what they've been doing for the past 10 years with Genia and Stratos Genomics

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High-Throughput Sequencing

Will Truveta out helix Helix?

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Proteomics

Ultima Genomics and Olink nab a population scale project

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Illumina

HOT TAKE: Illumina sees signals that the sequencing market is recovering

High-Throughput Sequencing

Automated sanger sequencing's fluorescent beginnings

We ‘completed’ the human genome in 2003, thanks mostly to commercial industrial engineering.

RNA

Direct RNA sequencing might tell us about more than just the bases

Post-transcriptional modifications: Why sequencing RNA directly is the future of transcriptomics

Transcriptomics

Transcriptomics is better with long-reads

Spoiler Alert: The holy grail of transcriptomics is long-reads.

Nanopores

Nanopores are getting on the rapid NICU/PICU sequencing bandwagon

Nanopores take on rapid neonatal sequencing

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HOT-TAKE

Will PacBio's new chemistry SPRQ renewed interest in clinical long-reads?

High-Throughput Sequencing

Checking your metrics is an important piece of the sequencing process

High throughput sequencing metrics: Don't be a monster, review them before sending data to the triage team.

High-Throughput Sequencing

Let the Nanopore Wars begin: BGI has a new nanopore sequencer

The Nanopore Wars are coming and BGI just fired the first salvo in what is sure to be an exciting conflict

High-Throughput Sequencing

Q-scores, what they mean, and why sometimes bigger isn't necessary

High throughput sequencing metrics: Q-scores, what are they good for?

High-Throughput Sequencing

Being accurate about sequencing accuracy

High throughput sequencing metrics: Let’s be accurate about accuracy.

High-Throughput Sequencing

In 2009, high throughput sequencing gave us our first glimpse of the 3-D organization of the DNA in our nuclei

While chromosomes are usually depicted as X's, they actually spend most of their time jumbled up like a giant ball of yarn.

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High-Throughput Sequencing

If you thought the sequencing wars were hot already, have you considered what a $10 genome might do to them?

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High-Throughput Sequencing

Another summer of sequencing is upon us. Whose sparkle will beguile the hearts of suitors and dazzle the eyes of onlookers?

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Genomic Sequencing Featured

Quest Diagnostics has made some moves in an attempt to become a major player in high throughput genomics