Brian Krueger

Microbiology

Real-Time monitoring of hospital pathogens pays dividends

Hospital genomic surveillance of pathogens stops outbreaks, prevents deaths and saves a bunch of money.

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June 9, 2025 Hey There! Thanks for spending part of your week with Omic.ly! This Week's Headlines 1) Real-Time monitoring of hospital pathogens pays dividends 2) Structural variant based MRD testing is coming to an oncologist near you 3) A Pile of Pennies 4) Weekly Reading List

Genomics

The genetics of pregnancy loss

10-20% of pregnancies end in miscarriage. Genetics is helping us to explain why that is!

Proteomics

Proteins! Nom Nom Nom Nom.

Single-cell and spatial proteomics - a more refined future.

DNA

The 2D structure of DNA was solved by someone you've probably never heard of before

Watson and Crick were the first to describe the structure of the DNA double helix. Their major contribution to science was, at its core, a synthesis of all of the best data available at the time.

Weekly Reading List

Weekly Reading List: June 2, 2025

Rare ‘ambidextrous’ protein breaks rules of handednessMost proteins are left-handed, but scientists have found an ancient molecule that works in both mirror-image forms.NatureEwen CallawayEuropean Sperm Donor Passes on Cancer Predisposition Variant to at Least 23 ChildrenA donor to a European sperm bank has transmitted a likely pathogenic variant for

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June 2, 2025 Hey There! Thanks for spending part of your week with Omic.ly! This Week's Headlines 1) The genetics of pregnancy loss 2) Proteins! Nom Nom Nom Nom. 3) The 2D structure of DNA was solved by someone you've probably never heard of before

CRISPR

CRISPR cures a metabolic disorder in an infant's liver

Will personalized gene-editing therapies become the standard of care for ultra-rare diseases?

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May 26, 2025 Hey There! If you were previously a paid subscriber, I've made it about 3/4 of the way through giving everyone partial (or full...) refunds. I should be able to finish that up this week. Stripe and my bank haven't been wanting to

Proteomics

Feeling like the dog that caught a car now that you have all this proteomic data?

So, once we have all of this amazing proteomic data, what do we do with it???

Molecular Biology

PCR has a more interesting history than you might have been told

The method below has been cited more than 600,000 times and is one of the most important developments in the history of science.

Weekly Reading List

Weekly Reading List: May 26, 2025

Covid 2020: An intimate look at health worker’s lives amid a global crisisTheatre nurse David Collyer wanted to shoot a documentary photography project in the last years of the Welsh hospital he worked in. Then Covid-19 appeared.BBCStephen DowlingIn its flagship journal, the CDC keeps publishing papers after firing

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HOT-TAKE

CRISPR baby cure, 23andMe gets bought, and Illumina FINALLY sues Element

Genetics

A gene for short sleep duration

Having trouble sleeping? A new mutation has been discovered that allows people to feel well rested after as little as 4hrs of sleep!

Proteomics

Structure equals function might be the most important phrase in proteomics

Proteomics: It’s all about the structures!

NIPT

Non-invasive prenatal testing is a big business. Here's how it got its start.

The two gels below spawned a multi-billion dollar industry that didn't exist prior to their publication in 1997.

Weekly Reading List

Weekly Reading List: May 19, 2025

A bespoke CRISPR therapy suggests a blueprint for treating ‘N-of-1’ diseasesA gene editing drug custom-made for a critically ill baby showed that, for some ultra-rare diseases, it’s possible to design and test a new CRISPR medicine in just a few months.BioPharma DiveBen FidlerDNA origami signal amplification in lateral

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May 19, 2025 Hey There! Thanks for spending part of your week with Omic.ly! There will be some changes around here, namely, you're going to start getting the weekly reading list for free and there will be bonus hot takes from time to time. Thanks for your

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Start-Upomics

Does bad blood run in the family? We're about to find out.

Genetics

De novo mutations are more common than we previously thought

There’s more to de novo mutations (DNMs) than just SNPs and indels.

Proteomics

Mass spec is primed to lead the next proteomics revolution

Mass Spec is leading the charge in bringing high-throughput proteomics to a lab near you.

DNA

The most famous picture in the history of genetics

The most famous photo in the history of genetics wasn’t generated by Watson and Crick, but that didn’t stop them from using it to solve the structure of DNA.

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Weekly Reading List

Weekly Reading List: May 12, 2025