NIPT Non-invasive prenatal testing is a big business. Here's how it got its start. The two gels below spawned a multi-billion dollar industry that didn't exist prior to their publication in 1997.
DNA The most famous picture in the history of genetics The most famous photo in the history of genetics wasn’t generated by Watson and Crick, but that didn’t stop them from using it to solve the structure of DNA.
Population Genetics Sequencing exomes in healthy populations pays dividends In a development that should surprise no one, population scale exome screening finds actionable variants.
Gene Expression The Lac Operon showed us that gene expression can be regulated 'If gene expression determines the function of a cell, it must be important to control that process?' Yes, very! Let me tell you about the PaJaMo experiment.
Genomics Just because it's in your genes, doesn't mean it's your fate One thing we constantly battle in genomics is, “What does it all mean?”
Genomic Mapping How genomic mapping finally helped to "complete" the human genome, kinda Did you know the human genome wasn't actually completed until 2022? No, seriously!
Molecular Biology Magnetic beads might be the most useful reagent in genomics Magnetic beads don't get much respect in the sequencing world, but they're hella useful. Here are some applications you should try!
Genomics Telomerase and how linear genomes attempt to stay long What if I told you that the ends of our chromosomes are a paradox and we didn't fully understand how human DNA was copied until 1989?
Genomics Rare diseases get a second opinion and new diagnoses A re-analysis of rare disease patients' genetic data delivers 500 new diagnoses
Genomics Science has figured out why Garfield is orange Thanks to some genetic sleuthing, we now understand why orange cats are orange.
Historical Paper Review A wormy discovery becomes a knockout laboratory technique One of the best ways to figure out what a gene does is to get rid of it and see what happens.
Genomics Pangenomes are here to bring equity to genomics Reference genomes: what they are and why the next big thing in genomics is the human pangenome.
Genomics Why short-read sequencing can't ever get us a 'whole genome' Short-reads miss things, or: How I learned to stop worrying and love the long-read.
Genomic Sequencing Frederick Sanger sequenced the first DNA genome, he didn't use 'Sanger Sequencing' to do it Frederick Sanger invented a famous DNA sequencing method. It's not the one pictured below (which he also invented).
RNA Bridge RNAs are here to take CRISPR's crown Move over CRISPR, bridge RNAs are here to make the precision genome edits that you can't.
Metabolome Metabolomics: Hype or Heroine? How does the promise of metabolomics stack up against our current reality? It’s complicated.
Multi-Omics Genetic Determinism: What it is and how we can avoid it with multi-omics One thing we constantly battle in genomics is, “What does it all mean?”
Genetics Barbara McClintock discovered a little thing called the transposable element in 1950 While everyone else was distracted by the structure of DNA, Barbara McClintock was discovering a little thing called the transposable element.
Genomics The evolutionary history of coffee is probably more complicated than you think That dark and delicious brew billowing clouds of irresistible coffee incense next to you is most likely the product of Coffea arabica.
